Josamycin (Josaxin) is an antibiotic in the Macrolide family. It is used to treat certain types of bacterial infection, particularly those caused by anaerobic bacteria.

Josamycin is rarely used as an acne treatment. Laboratory testing indicates that the acne-causing P. acnes is moderately susceptible to this antibiotic. Additionally, Josamycin may retain antibacterial activity against some P. acnes bacteria that are resistant to other Macrolide antibiotics (eg. Erythromycin).

Josamycin has a moderately short half-life and is often taken multiple times a day. This drug is not recommended for people with liver problems. Josamycin is not approved for human use in all countries.