Levofloxacin (Levoflox) is an antibiotic in the Quinolone family. It is used to treat a range of bacterial infections, including respiratory, eye and urinary tract infections.

Levofloxacin is rarely used as an acne treatment. However, laboratory testing indicates that the acne-causing P. acnes bacterium is generally susceptible to this antibiotic. Several studies have indicated that oral Levofloxacin may be more effective at controlling acne symptoms than other members of the Quinolone antibiotic family (eg. Ciprofloxacin).

Levofloxacin is available in oral and topical formulations. Oral Levofloxacin is a more commonly used as an acne treatment than topical Levofloxacin. Topical Levofloxacin is generally available as an opthalmic ointment, but these medications can be applied directly to the skin.