Linezolid (Zyvox) is an antibiotic in the Oxazolidinone family. Linezolid is used to treat certain types of skin and respiratory infections. It has antibacterial activity against many Gram-positive bacteria, including the acne-causing P. acnes bacterium.

Linezolid is rarely used as a treatment for acne. Linezolid is only recommended for short-term use, long-term use of Linezolid can cause significant side effects. Therefore, the utility of Linezolid as an acne treatment would be limited to short-term use for the purpose of treating acute cases of severe inflammatory acne.

Linezolid is a relatively new antibiotic that was approved by the FDA (United States) in 2000. In many countries where generic Linezolid is not available (eg. United States) this medication can be very expensive.