Lymecycline (Tetralysal) is an antibiotic in the Tetracycline family. It is used to treat certain types of respiratory, skin and sexually-transmitted bacterial infections.

Lymecycline is occasionally used as an acne treatment, but is a less common treatment for acne than other Tetracycline family antibiotics (eg. Minocycline, Doxycycline). Lymecycline is administered orally when used as an acne treatment.

Lymecycline can be an effective treatment for mild to severe acne symptoms in some patients. Clinical testing has indicated that the efficacy of Lymecycline as an acne treatment is comparable to that of Minocycline. Unfortunately, acne-causing P. acnes bacteria that are broadly resistant to Tetracycline family antibiotics (including Lymecycline) are becoming common in many regions of the world. Because the increase in tetracycline-resistant P. acnes bacteria, this family of antibiotics is ineffective for many patients.