Minocycline (Minocin) is a broad spectrum antibiotic in the Tetracycline family. It is used to treat a wide range of bacterial infections, including Lyme disease and acne.

Minocycline is one of the most commonly prescribed oral antibiotics for the treatment of acne symptoms. There is a large amount of clinical research and numerous patient reports that demonstrate Minocycline can significantly improve acne symptoms for many individuals. However, Minocycline is not an effective acne treatment for all people.

Laboratory antibiotic susceptibility testing indicates that the acne-causing P. acnes bacteria is generally very sensitive to Minocycline. However, Minocycline-resistant P. acnes bacteria are becoming common in many regions of the world. This problem is particularly widespread in Europe and North America. Patients with acne caused by these resistant bacteria are unlikely to benefit from treatment with Minocycline, or other Tetracycline family antibiotics (eg. Doxycycline).

Minocycline tends to be a little more effective at improving acne symptoms than Doxycycline and Tetracycline. However, the risk of side effects when using Minocycline is a little higher than with Doxycycline.