Nitrofurantoin (Macrodantin) is an antibiotic that is used to treat certain kinds of bacterial infections, primarily urinary tract infections. Nitrofurantoin is not a commonly used antibiotic, but the increasing incidence of antibiotic-resistant bacteria has generated renewed interest in this medication.

Nitrofurantoin is rarely used as a treatment for acne. There is very little clinical or laboratory research into the effectiveness of Nitrofurantoin as a treatment for active acne symptoms, or into the sensitivity of the acne-causing P. acnes bacterium to this antibiotic. However, laboratory testing does indicate that gram-positive bacteria, a group which includes P. acnes, tend to be susceptible to Nitrofurantoin.

Additional clinical testing and patient surveys will be required to evaluate the utility of Nitrofurantoin as a component of acne treatment regimens.