Ofloxacin (Floxin) is an antibiotic in the Quinolone family. Ofloxacin is a mixture of two closely related molecules, Levofloxacin and Dextrofloxacin. Levofloxacin provides the majority of the antibacterial activity of Oflaxcin. The use of Oflaxcin has declined in recent years as a pure Levofloxacin (Levaquin) has become more widely available.

Ofloxacin is rarely used to treat active acne. There is little clinical research about the efficacy of Ofloxacin as a treatment for acne. However, laboratory antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium is generally sensitive to Quinolone family antibiotics, including Ofloxacin.

Ofloxacin is available in oral and topical formulations. For the treatment of acne, other Quinolone family antibiotics (eg. Levofloxacin, Moxifloxacin, Ciprofloxacin) are generally preferred over Ofloxacin.

Topical Ofloxacin may be useful as an acne treatment. But laboratory and clinical research suggest that other topically-applied Quinolones (eg. Nadifloxacin) may be better suited for use in treating acne.