Pristinamycin (Pyostacine) is an antibiotic that is used to treat certain types of infections caused by gram-positive bacteria (eg. Staph infections). Pristinamycin is a natural combination of two complementary antibiotics – Pristinamycin IA an Pristinamycin IIA. Pristinamycin IA is a cyclic hexadepsipeptide antibiotic, and Pristinamycin IIA is in the Macrolide family of antibiotics.

Pristinamycin is rarely used as an acne treatment, but laboratory testing indicates that the acne-causing P. acnes bacterium is susceptible to Pristinamycin. Pristinamycin is occasionally used to treat non-acne infections that are caused by P. acnes bacteria.

Pristinamycin is only available in a few countries. But in countries where it is available, Pristinamycin is an antibiotic that warrants further investigation as an acne treatment.