Spiramycin (Spirex) is an antibiotic in the Macrolide family. It has both antibacterial and antiparasitic properties. Spiramycin is used to treat a limited range of infections, and this medication is not available in all countries.

Spiramycin is rarely used as a treatment for acne. There is minimal clinical research into the efficacy of Spiramycin as an acne treatment. Other members of the Macrolide family (eg. Erythromycin, Azithromycin, etc) are more widely available and commonly used. Laboratory testing indicates that the acne-causing P. acnes bacteria is less susceptible to Spiramycin than to other Macrolide family antibiotics.