Cefpodoxime (Cefpo) is an antibiotic in the Cephalosporin Family. Cefpodoxime is used to treat a range of infections, including gonorrhoea, tonsillitis, pneumonia, and bronchitis.

Cefpodoxime is rarely used as an acne treatment. However, laboratory research indicates that the acne causing P. acnes bacteria tend to be susceptible to Cephalosporin family antibiotics, including Cefpodoxime. There is currently little clinical research and few patient reports on the efficacy of Cefpodoxime for the treatment of acne symptoms.