Cloxacillin (Cloxapen) is an antibiotic in the Penicillin family. It is used to treat several types of bacterial infections.

Cloxacillin is rarely used for the treatment of acne symptoms. However, laboratory research indicates that the acne-causing P. acnes bacteria is highly sensitive to Penicillin family antibiotics, such as Cloxacillin. There is little clinical research and few patient reports about the efficacy of Cloxacillin as an acne treatment.