Dapsone is an antibiotic in the Sulfonamide family. It is used to treat a range of infections, including Leprosy, respiratory and skin infections.

Dapsone was a popular choice for treating moderate to severe acne in the mid 20th century. But the use of dapsone as an acne treatment declined when oral Isotretinoin (Accutane) was introduced. However, Dapsone is now regaining popularity as an acne treatment.

Antibiotic susceptibility testing indicates that the acne-causing P. acnes bacterium tends to be moderately susceptible to Dapsone. A wealth of clinical research demonstrates that oral Dapsone can be an effective treatment for individuals with inflammatory acne. Patients have also reported positive results from the use of topical Dapsone gel.

Dapsone is widely available in oral and topical formulations. Topical Dapsone is a relatively new formulation that is specifically marketed as an acne treatment. Cotrimoxazole (also in the Sulfonamide antibiotic family) is more commonly used oral antibiotic than Dapsone, but it is unclear which of these medications is a more effective acne treatment.