Flucloxacillin (Floxapen) is an antibiotic in the Penicillin family. Flucloxacillin is a narrow-spectrum antibiotic that is used to treat a subset of respiratory, skin and other bacterial infections.

Flucloxacillin is rarely used to treat acne. Laboratory research indicates that the acne-causing P. acnes bacterium is susceptible to Penicillin family antibiotics, including Flucloxacillin. But there is little clinical research into the efficacy of Flucloxacillin as a treatment for acne.

Flucloxacillin is not currently available in all countries.