Mafenide is an antibiotic in the Sulfonamide family. Mafenide is a topical antibiotic that is used to treat certain kinds of skin infections. It is commonly used to treat burn injuries and prevent secondary infections.

Mafenide is rarely used as an acne treatment. However, there have been some patient reports that suggest that Mafenide can be a useful treatment for people with mild to moderate acne symptoms. Laboratory testing indicates that the acne-causing P. acnes bacterium tends to be moderately sensitive to Sulfonamide family antibiotics, such as Mafenide.

Topical Mafenide may be most effective when combined with a complementary treatment as part of a comprehensive acne treatment plan.