Retapamulin is a an antibiotic in the Pleuromutilin family. It is used as a topical treatment for certain kinds of skin bacterial infections, including acne.

Retapamulin is a relatively new antibiotic that is quickly becoming a popular treatment for acne. In laboratory testing, Retapamulin has shown excellent antibacterial activity against the acne-causing P. acnes bacterium. Research and patient reports also suggest that Retapamulin can be an effective acne treatment, particularly when combined with complementary therapies (eg. Oral Antibiotics, Retinoids, Light and Laser Therapies, etc).

Retapamulin is still under patent protection and this antibiotic can be substantially more expensive than many other topical acne treatments. It may not be available in all regions.