Rifabutin (Mycobutin) is an antibiotic in the Rifamycin family. It is primarily used in the treatment of mycobacterial infections (eg. tuberculosis).

Rifabutin is rarely used for the treatment of acne and their is very little clinical research into the efficacy of Rifabutin as an acne treatment.

Rifabutin is active against many gram-positive bacteria, including the acne-causing Propionibacterium acnes. Laboratory testing indicates that P. acnes bacteria are very sensitive to Rifamycin family antibiotics, including Rifabutin.

Rifamycin family antibiotics may be useful components of acne treatment regimens, particularly for individuals with moderate to severe acne symptoms. But more clinical research and patient reports are needed to evaluate the utility of this family of antibiotics for the treatment of acne.