Rifapentine (Priftin) is an antibiotic in the Rifamycin family. It is an important component of the combination antibiotic therapy used to treat tuberculosis, and other mycobacterial infections.

Rifapentine is not generally used in the treatment of acne. Laboratory testing indicates that the acne-causing Propionibacterium acnes bacterium is highly sensitive to Rifamycin family antibiotics, including Rifapentine.

Rifapentine and other Rifamycin family antibiotics may be useful components of comprehensive treatment regimens for people with severe acne symptoms. Additional clinical research and patient reports are needed to evaluate the utility of this family of antibiotics for the treatment of acne.