Sulfacetamide is a topical antibiotic in the Sulfonamide family. It is used to topically to treat certain types of skin infections, including acne. Sulfacetamide is available in topical formulation by itself or in combination with Sulfur.

Sulfacetamide is commonly used to treat acne symptoms and it is marketed directly for this purpose. Research and patient reports indicate that Sulfacetamide is effective for some patients, particularly those with mild to moderate acne symptoms. Laboratory antibiotic susceptibility testing indicates that that the acne-causing P. acnes bacterium tends to be moderately susceptible to Sulfonamide family antibiotics, such as Sulfacetamide.