Sulfathiazole (Sulfatiazol) is an antibiotic in the Sulfonamide family. It is used as a topical antibacterial to prevent and treat bacterial infections of the skin.

Sulfathiazole is occasionally used as a topical treatment for acne. This medication is often combined with other antibiotics (eg. Penicillin, Trimethoprim) in topical antibacterial ointments.

There is limited clinical or laboratory research into the effectiveness of Sulfathiazole for the treatment of acne symptoms. However, laboratory testing does indicate that the acne-causing P. acnes bacterium tends to moderately susceptible to antibiotics in the Sulfonamide family, such as Sulfathiazole.

Topical ointments that combine Sulfathiazole with a complementary antibiotic (eg. Penicillin G) are more likely to be effective at improving acne symptoms than Sulfathiazole alone. Topical Sulfathiazole may better control acne symptoms when be combined with complementary therapies.

A very old medical report (1951) suggested that direct injection of a Sulfathiazole solution into inflammatory acne cysts was an effective treatment, but this approach has not been widely practiced. Other members of the Sulfonamide family (eg. Dapsone, Silver Sulfadiazine, Sulfacetamide) are more commonly used as topical treatments for acne.